Trump Receives Experimental Drug For Covid-19. Here's What Doctors Are Watching For

President Trump will be staying in the presidential suite at the Walter Reed National Military Medical Center for the next few days, according to the White House.

The president's doctor says he is experiencing "mild symptoms" after testing positive for coronavirus. But the president has already received a single dose of Regeneron's polyclonal antibody cocktail, an experimental drug that has shown promise in initial trials in improving symptoms and reducing virus levels in the body. The drug is currently being evaluated but has not yet received FDA approval.

Trump "completed the infusion without incident," White House physician Sean Conley wrote in a memo released Friday, adding, "As of this afternoon, the President remains fatigued but in good spirits."

But, given the president's age, 74, and his weight, 244 pounds, doctors say he's at higher risk of serious illness. The Centers for Disease Control and Prevention has found that COVID-19 patients in their early to mid 70s are five times more likely to be hospitalized, and much more likely to die, compared to people in their 20s.

With a BMI of just over 30, Trump is technically obese. And though he does not drink alcohol or smoke, he has other possible risk factors. The president has a history of elevated cholesterol, which he takes a statin medication to control. In addition, his doctors have previously reported calcium build up in his blood vessels in the mild to moderate range.

COVID-19 is unpredictable, ranging from very mild to severe cases, so it's not yet clear how Trump will fare in the coming days. Experts we consulted say Trump's doctors will likely monitor him closely and can consider a range of treatments and therapies, beyond Regeneron's antibody cocktail, if his condition deteriorates. Here's a list of things doctors will be watching for.

What treatments and therapies are Trump's doctors likely to consider?

In addition to the antibody cocktail, Trump's physician says the president has also been taking zinc, which is known to affect the immune system, and Vitamin D supplements.

For now, the president will likely be getting supportive care, says Dr. Colleen Kraft, an infectious disease physician and associate chief medical officer at Emory University Hospital in Atlanta.

For a fever, he'd be given fever-reducing medicines, such as Tylenol. And doctors say it's important for Trump to get plenty of rest, drink lots of fluids and eat well. Doctors will likely monitor the president closely and hold off on any of other medicines or therapies unless his condition deteriorates.

If Trump were to get sick enough to need supportive oxygen, that's when doctors might turn to therapies such as remdesivir, which is delivered intravenously, or the steroid dexamethasone, says Dr. Panagis Galiatsatos, a pulmonary and critical care physician at Johns Hopkins School of Medicine, who has been treating COVID-19 patients. "If his X-rays look horrible, like pneumonia has developed, he's getting antibiotics."

Symptoms can change quickly, so how will the president's doctors monitor any changes?

President Trump's medical team will likely monitor his temperature, heart rate, blood pressure and oxygen saturation.

"They'll be paying attention to all of his vital signs," says Galiatsatos.

Since some people with COVID-19 have had low oxygen levels before they noticed a shortness of breath, monitoring the blood oxygen with a pulse oximeter can help detect a problem sooner. Galiatsatos says, "What we have recognized with COVID-19 is that the majority of patients, when they get sick, [don't have an] all-at-once decline." Symptoms can progress gradually, so constant monitoring is key.

What tests will Trump's doctors consider?

Trump "is a high-risk patient," says Dr. Faisal Masud, medical director of critical care at Houston Methodist Hospital, so a range of tests would be appropriate. Masud says if he were on the president's medical team, he would do a CT scan of the chest to check his lungs and an ultrasound of the heart to help evaluate his heart function. He'd also order blood tests to check a number of markers for inflammation, and would also check markers for kidney function.

Do Trump's current mild symptoms indicate anything about his prognosis?

No. "Having mild symptoms on day one does not mean you're going to have mild symptoms for the rest of your course," says Galiatsatos.

Of course, it's possible that Trump may not develop any further symptoms, Galiatsatos adds. But he says that given Trump's age, his weight, and his gender (men tend to do worse with COVID-19 than women), the president has "several strikes against him."

"These are strikes that raise the probability that his COVID-19 may go from mild to severe," Galiatsatos says.

However, even if Trump's symptoms do get worse, doctors have learned a great deal about treating COVID-19 in the last 10 months, says Kraft. And as president, she notes, Trump is expected to get the most sophisticated care currently available. "I expect that the president, with the attention that he will get, should do well," Kraft says. [Copyright 2020 NPR]